Speaker:
Dr. Kyan D'Angelo, University of California Berkeley
The Department of Chemistry is excited to host Dr. Kyan D'Angelo (University of California, Berkeley) on Wednesday, February 12, 2025 for a departmental seminar.
"Simplifying Complex Molecule Synthesis and Functionalization"
The most powerful transformations in the synthesis of complex molecules generate significant structural complexity from simple precursors. In many cases, however, there is no practical approach available to translate intuitive retrosynthetic disconnections of a given target from the blackboard to the lab. This presentation will highlight strategies that address such challenges toward the synthesis and functionalization of bioactive complex molecules. These developments include a late-stage dimerization reaction applied to the total synthesis of the natural product himastatin, site-selective C-H borylation reactions of saturated heterocycles, and stereoselective glycosylation reactions of minimally protected sugars. Complex mechanistic questions concerning the fundamental reactivity and bioactivity of these molecules will be addressed throughout.
To learn more about Dr. D'Angelo's research, please visit: https://hartwig.cchem.berkeley.edu/members/Kyan_D'Angelo
Seminar Host: Prof. Matthew Becker
Chemistry Seminar Series