The MacAlpine Lab is interested in understanding the mechanisms by which the molecular architecture of the chromosome regulates fundamental biological processes such as replication and transcription. Specifically, how are replication, transcription, and chromatin modification coordinated on a genomic scale to maintain genomic stability? We are addressing this question by using genomic, computational, and biochemical approaches in the model organisms Saccharomyces cerevisiae and Drosophila melanogaster.

For the latest information on the MacAlpine Lab, please visit our website.