MEMS Seminars: Driving innovation of pharmaceutical products through mechanistic understanding

MEMS Seminar Series Presents Dr. Marcial Gonzalez, Purdue University Multi-scale modeling, simulation and characterization of particulate products processing and performance: Driving innovation of pharmaceutical products through mechanistic understanding Location: Fitzpatrick Schiciano B 1466 Zoom: https://duke.zoom.us/j/91709780711 Abstract: Powder compaction plays a relevant role in many pharmaceutical, food, ceramic and metallurgical manufacturing processes, so much so that microstructure evolution during consolidation has a direct impact on the end-product properties and performance. This process involves a variety of coupled physical mechanisms at the particle-scale (e.g., elasto-plastic deformations, formation of solid bridge, friction, and fracture) that govern the properties and performance of the final product (i.e., tablet hardness, swelling, disintegration and dissolution for pharmaceutical powders pressed into solid tablets for oral administration). Therefore, it is of paramount importance to fundamentally understand these coupled mechanisms in order to optimize manufacturing processes and to improve product design.